MDPV Introduction:

3,4-Methylenedioxypyrovalerone (MDPV) is a designer drug of the phenethylamine class.MDPV For Sale Online MDPV is structurally related to cathinone, an active alkaloid found in the khat plant, 3,4 methylenedioxymethamphetamine (MDMA), methamphetamine, and other schedule I phenethylamines. MDPV, like some other substances in this class, is a central nervous system (CNS) stimulant. MDPV is also reported to have hallucinogenic effects. MDPV has been identified in products that are falsely marketed as “bath salts,” “plant food,” and “research chemicals” and is sold over the Internet and at local retail shops. MDPV For Sale Online

 Licit Uses:
MDPV is not approved for medical use in the United States.

Chemistry: MDPV For Sale Online

MDPV (1-(1,3-Benzodioxol-5-yl)-2-(1-pyrrolidinyl)-1- pentanone; Chemical Abstract Service Number 687603-66-3) is related in chemical structure to schedule I hallucinogenic substances (MDMA, MDEA) and to schedule I stimulants (cathinone, methcathinone). Its molecular
formula is C16H21NO3 and its molecular weight is 275 g/mol. MDPV has a high melting point (estimated at 200oC) and is a solid at room temperature. The chemical structure is shown below.

Pharmacology:

MDPV has been shown to bind to recombinant human dopamine, norepinephrine and serotonin transporters and to inhibit uptake of the corresponding substrate neurotransmitter in vitro. MDPV has been shown to inhibit the rat brain synaptosomal uptake of dopamine and norepinephrine with high potency but has weak effects on serotonin uptake in vitro. It has been demonstrated that MDPV increases extracellular concentration of dopamine in rodent brain as measured by in vivo microdialysis technique.

MDPV has been shown to increase locomotor activity, heart rate and blood pressure in rodents. In drug discrimination tests, MDPV fully substitutes for methamphetamine in rats trained to discriminate methamphetamine from saline. In mice trained to discriminate MDPV from saline, methamphetamine and MDMA fully substituted MDPV. Intravenous selfadministration studies have shown that rats readily and dose-dependently self-administer MDPV and extended access leads to escalation of drug intake similar to that reported for stimulants such as cocaine and methamphetamine.

MDPV has been reported to induce subjective effects in humans similar to those induced by cocaine, amphetamine, and MDMA. The subjective effects induced by substituted cathinones are feelings of empathy, stimulation, alertness, euphoria, and awareness of senses. Other effects reported from the use of MDPV were tachycardia, hypertension, vasoconstriction, and sweating. MDPV has also been reported to cause intense, prolonged panic attacks in users. Repeat users have reported bouts of psychosis and a craving or a strong desire or urge to use again. There have been reports of deaths in which MDPV was either implicated or ruled as the cause of
death.

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Users of MDPV anecdotally reported that they take 25 mg or less per session. The duration of the subjective effects is about two to three hours whereas the adverse effects have been reported lasting six to eight hours after administration.

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